Yonne (French: [jɔn]) is a département in the Bourgogne-Franche-Comté region in France. It is named after the river Yonne, which flows through it, in the country's north-central part. One of Bourgogne-Franche-Comté's eight constituent departments, it is located in its northwestern part, bordering Île-de-France. It was created in 1790 during the French Revolution. Its prefecture is Auxerre, with subprefectures in Avallon and Sens. Its INSEE and postcode number is 89.

Yonne is Bourgogne-Franche-Comté's fourth-most populous department, with a population of 335,707 (2019). Its largest city is its prefecture Auxerre, with a population of about 35,000 within city limits and 68,000 in the urban area.